Scientific Literature

Feature Article
The Functions of Tomato Lycopene and Its Role in Human Health
 
 
Antioxidant Support
Processing effects on lycopene content and antioxidant activity of tomatoes.
Evaluation of the Evidence on the Role of Tomato Products in Disease Prevention.
The antioxidant properties of lycopene.
Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene.
 
Cancer of the digestive tract
A cohort study of nutritional factors and endometrial cancer
Mediterranean Epidemiological Evidence on Tomatoes and the Prevention of Digestive-Tract Cancer
Determinants of Plasma Anti-oxidant Vitamin Levels in a Population at High Risk for Stomach Cancer
Inhibitory effects of natural carotenoids, a-carotene, b-carotene, lycopene and lutein, on colonic aberrant crypt foci in rats
Isomerization of lycopene in the gastric milieu
 
Cardiovascular Health
Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.
Role of antioxidant lycopene in cancer and heart disease.
Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis
Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification
Antioxidant Consumption During Exercise in Intermittent Claudication
 
Disease of the central nervous system
Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis.
 
Eye health
Serum Antioxidants and Age-Related Macular Degeneration in a Population-Based Case-Control Study
Plasma antioxidant vitamins and carotenoids and age related cataract
Inhibitory effect of lycopene on cataract development in galactosemic rats
 
Lung Health
Colorful cancer prevention: carotene, lycopene, and lung cancer
Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts
Beta-Carotene Increases Lung Cancer Incidence in Cigarette Smokers
Plasma Concentrations of Carotenoids and Tocopherols in Male Long-Term Tobacco Chewers, Smokers and Nonusers
Plasma Levels of b-Carotene, Lycopene, Canthaxanthin, Retinol, and a- and t-Tocopherol in Cervical Intraepithelial Neoplasia and Cancer
Effect of smoking on serum nutrient concentrations in African-American women
 
Prostate Health
Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise
Oxidative DNA damage in prostate cancer patients consuming tomato-sauced based entrees as a whole-food intervention
A prospective study of tomato products, lycopene and prostate cancer risk
Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy.
Response of hormone refractory prostate cancer to lycopene
Serum and Tissue Lycopene and Biomarkers of Oxidation in Prostate Cancer Patients: A Case-Control Study
Lycopene in Association with alpha-Tocopherol Inhibits at Physiological Concentrations Proliferation of Prostate Carcinoma Cells
Cohort Study of Diet, Lifestyle, and Prostate Cancer in Adventisit Men
A Case-control study of diet and prostate cancer
Intake of Carotenoids and Retinol in Relation to Risk of Prostate Cancer
Cis-trans Isomers of Lycopene and Beta-Carotene in Human Serum and Tissues
 
Skin Health
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
Supplementation with ß-Carotene or a Similar Amount of Mixed Carotenoids Protects Humans from UV-Induced Erythema
Dietary carotenoids contribute to normal skin color and UV photosensitivity
Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblasts
Dietary tomato paste protects against ultraviolet light-induced erythema in humans.
Evidence for antioxidant nutrients-induced pigmentation in skin: Results of a clinical trial.
Skin lycopene is destroyed preferentially over beta-carotene during ultraviolet irradiation in humans
 
Tomatoes, lycopene, and cancer risk
Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.
 
Women's Health
Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women
Carotenoids, alpha-tocopherols, and retinol in plasma and breast cancer risk in northern Sweden
Acute Phase Response and Plasma Carotenoid Concentrationsin Older Women: Findings From the Nun Study
Effects of Lycopene, a Carotenoid, on Inthrathymic T cell Differentiation and peripheral CD4/CD8 ratio in a High Mammary Tumor Strain of SHN Retired Mice
Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells.
Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes.
 
Other
Lycopene: Its Role in Human Health and Disease
Lycopene supplementation attenuates the inflammatory status of colitis in a rat model
Uptake and Disposition of Lycopene and Carotenoids in Rats
Metabolic engineering of beta-carotene and lycopene content in tomato fruit
Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass
Effect of high-pressure treatment on the carotenoid composition and the radical scavenging activity of persimmon fruit purees
Supercritical CO2 extraction of beta-carotene and lycopene from tomato paste waste
The Potential Role of Lycopene for Human Health
Absorption and Transport of Carotenoids
Carotenoids Up-Regulate Connexin43 Gene Expression Independent of Their Provitamin A or Antioxidant Properties

Where to find lycopene

Unlike other fruits and vegetables, where nutritional content such as vitamin C is diminished upon cooking, processing of tomatoes increases the concentration of bioavailable lycopene...


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Natural vs. Synthetic

Why it is so important to look for natural sources of lycopene in your functional foods and supplements?


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Lycopene Buyer's Guide

You can find natural tomato lycopene in your local health food retail stores.


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Gazpacho Meets Bloody Mary 9/4/2008
Cold gazpacho sizzles with lycopene and antioxidants   
Two ways to get the latest on lycopene and all of the areas it benefits: