Protecting from DNA damage
In a double-blind, cross-over study plasma and lymphocyte carotenoid levels increased significantly in healthy subjects who consumed daily Lyc-O-Mato for 26 days.
The intake of Lyc-O-Mato significantly reduced DNA damage in lymphocytes subjected to oxidative stress.
Lycopene and prostate health
Tomato extract supplementation modulated both nuclear factor-2 (erythroid derived-2)-mediated oxidative stress response and male androgen levels in healthy prostate tissue of prostate cancer patients.
Magbanua, M. J et al. PLoS.One. 2011;6(9):e24004
The largest blood-based study was the Physicians’ Health Study-
a nested case-control study using samples stored in 1982.
The baseline plasma lycopene level of cases was compared with that of age-matched prostate cancer-free controls.
A lower risk of prostate cancer, particularly for aggressive prostate cancer (RR = 0.56; 95% CI = 0.34–0.92) was found when comparing high with low quintile of plasma lycopene.
Gann PH et al. Cancer Res. 1999
DECREASES PSA LEVELS
Schwarz et al, J. Nutr, 2008
LYCOPENE INGIBITS PROSTATE
Schwarz et al, J. Nutr, 2008
Correlation of lycopene forehead-skin levels with decreased roughness and increased smoothness.
Lycopene levels were inversely correlated with skin roughness in 15 female and 5 male between the ages of 40 and 50 years.
Darvin M, Eur J. Pharm and Biopharm, 2008
In a 12-week single blind, randomized clinical trial, tomato extract protected the skin from UV induced erythema.
Aust O, et.al. 2005. Int J Vitam Nutr Res. 75(1):54-60
Lycopene-rich tomato paste has also been shown to mitigate UV radiation-induced elevation in procollagen (pC)-I deposition and reduction in matrix metalloproteinase-1 (MMP-1)
Rizwan, M et al Br.J.Dermatol. 2011;164(1):154-162.
Lycopene and bone health
A longitudal study (17 years) on the correlation between carotenoid intake and risk for hip fracture in post-menopausal women has demonstrated a protective effect of high lycopene plasma levels (equivalence to ~12 mg/d lycopene consumption) from hip fractures.
Sahni S et al, Am J Clin Nutr, 2009
Post-menopausal women on a 30-days lycopene-restricted diet showed a 20% increase plasma levels of a marker of bone resorption (NTx).
Mackinnon ES et al, Osteoporos Int, 2011
Tomato extract, both alone and in combination with conventional antihypertensive medications, decreased systolic and diastolic blood pressure and reduced levels of lipid peroxidation products.
Engelhard, Y. N. et alAm Heart J 2006;151:100.
Paran, E et al. Cardiovasc.Drugs Ther. 2009;23(2):145-151
tomato extract effect
Stage 1 hypertensive subjects
Stage 1 hypertensive subjects treated but uncontrolled
Pre-hypertensive, otherwise healthy subjects
Significant reduction of SBP was achieved as early as the sixth week of treatment (p=0.038)
Engelhard Y. Paran E.; Am. Heart J; 2006,151: 100